HPLC & UHPLC Analytical Columns

Raptor ARC-18 LC Columns (USP L1)

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  • Ideal for high-throughput LC-MS/MS applications with minimal sample preparation.
  • Well-balanced retention profile for better detection and integration of large, multiclass analyte lists.
  • Sterically protected to endure low-pH mobile phases without sacrificing retention or peak quality.
  • Part of Restek’s Raptor LC column line featuring 2.7 and 5 µm SPP core-shell silica.

Raptor Biphenyl LC Columns (USP L11)

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  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Restek’s most popular LC stationary phase applied to 2.7 and 5 µm Raptor SPP core-shell silica.

Raptor FluoroPhenyl LC Columns (USP L43)

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  • Capable of both reversed-phase and HILIC separations.
  • Ideal for increasing sensitivity and selectivity in LC-MS analyses.
  • Offers increased retention for charged bases.
  • Part of Restek’s Raptor LC column line featuring 2.7 and 5 μm SPP core-shell silica.
  • Switch to a Raptor FluoroPhenyl LC column when you need more retention and selectivity for basic and hydrophilic compounds than you can achieve on a C18.

Raptor HILIC-Si LC Columns (USP L3)

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  • HILIC silica column designed for increased retention of polar compounds without ion-pairing reagents.
  • 2.7 µm Raptor core-shell particles provide the speed of SPP, with greater efficiency and capacity than 5 µm particles.
  • Ideal for increasing sensitivity and selectivity in LC-MS analyses.
  • Fully compatible with both HPLC and UHPLC when using low backpressure HILIC mobile phases.
  • Switch to a Raptor HILIC-Si LC column when you need more retention and resolution of hydrophilic, polar analytes.

Force FluoroPhenyl LC Columns (USP L43)

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  • Capable of both reversed-phase and HILIC separations.
  • Ideal for increasing sensitivity and selectivity in LC-MS analyses.
  • Offers increased retention for charged bases.

Force C18 LC Columns (USP L1)

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  • A traditional end-capped C18 ideal for general-purpose use in reversed-phase chromatography.
  • Wide pH range (2–8) provides excellent data quality for many applications, matrices, and compounds.
  • Offers high hydrophobic retention.

Force Biphenyl LC Columns (USP L11)

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  • Ideal for bioanalytical testing applications like drug and metabolite analyses.
  • Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
  • Limits ionization suppression and allows simple, MS-friendly mobile phases.
  • Restek’s most popular LC stationary phase.

Ultra Biphenyl Columns (USP L11)

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Particle Size: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 15%
End-Cap: yes
pH Range: 2.5 to 8
Temperature Limit: 80 °C
USP Phase: L11
Phase Category: phenyl
Ligand Type: unique Biphenyl

USLC Method Development Toolbox

All the Right ToolsAll in One Toolbox

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  • Ultra Selective Liquid Chromatography (USLC) method development toolbox contains all four USLC stationary phases in one convenient package.
  • Available for UHPLC (1.9 μm) and HPLC (3 or 5 μm) in 50, 100, or 150 mm lengths.

Allure Silica Columns (USP L3)

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Particle Size: 5 µm, spherical
Pore Size: 60Å
Surface Area: 450 m2/g
End-cap: no
pH Range: 2.5 to 8
Temperature Limit: 80°C

Highly retentive phase for normal phase separations. Very high surface area, Type B silica packing.

Ultra C8 Columns (USP L7)

Excellent for a wide range of analyses

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Particle Size: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 12%
End-Cap: yes
pH Range: 2.5 to 8
Temperature Limit: 80 °C
USP Phase Code: L7
Phase Category: C8, octylsilane
Ligand Type: monomeric C8

Ultra IBD Columns (USP L68)

Specialized Columns for Mixed Polar and Nonpolar Compounds

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Particle Size: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 12%
End-Cap: no
pH Range: 2.5 to 8
Temperature Limit: 80 °C
USP Phase Code: L68
Phase Category: polar-embedded alkyl
Ligand Type: proprietary polar functional embedded alkyl

Raptor EtG/EtS LC Column

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  • Proven performance for accurate, reliable ethyl glucuronide (EtG) and ethyl sulfate (EtS) analysis.
  • Strong retention consistently resolves analytes from matrix interferences.
  • Long column lifetime ensures consistent performance injection after injection.
  • Fast, 4-minute, dilute-and-shoot LC-MS/MS analysis supports high sample throughput.

Ultra PFP Propyl Columns (USP L43)

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Particle Size: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 11%
End-Cap: yes
pH Range: 2.5 to 8
Temperature Limit: 80 °C
USP Phase Code: L43
Phase Category: fluorophenyl propyl
Ligand Type: pentafluorophenyl propyl