HPLC & UHPLC Analytical Columns

• Ideal for high-throughput LC-MS/MS applications with minimal sample preparation.
• Well-balanced retention profile for better detection and integration of large, multiclass analyte lists.
• Sterically protected to endure low-pH mobile phases without sacrificing retention or peak quality.
• Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.

• Ideal for bioanalytical testing applications like drug and metabolite analyses.
• Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
• Limits ionization suppression and allows simple, MS-friendly mobile phases.
• Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.

• Capable of both reversed-phase and HILIC separations.
• Ideal for increasing sensitivity and selectivity in LC-MS analyses.
• Offers increased retention for charged bases.
• Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.
• Switch to a Raptor FluoroPhenyl LC column when you need more retention and selectivity for basic and hydrophilic compounds than you can achieve on a C18.

• HILIC silica column designed for increased retention of polar compounds without ion-pairing reagents.
• 2.7 µm Raptor core-shell particles provide the speed of SPP, with greater efficiency and capacity than 5 µm particles.
• Ideal for increasing sensitivity and selectivity in LC-MS analyses.
• Fully compatible with both HPLC and UHPLC when using low back-pressure HILIC mobile phases.
• Switch to a Raptor HILIC-Si LC column when you need more retention and resolution of hydrophilic, polar analytes.

• Capable of both reversed-phase and HILIC separations.
• Ideal for increasing sensitivity and selectivity in LC-MS analyses.
• Offers increased retention for charged bases.

• A traditional end-capped C18 ideal for general-purpose use in reversed-phase chromatography.
• Wide pH range (2–8) provides excellent data quality for many applications, matrices, and compounds.
• Offers high hydrophobic retention.

• Ideal for bioanalytical testing applications like drug and metabolite analyses.
• Heightened selectivity and retention for compounds that are hard to resolve or elute early on C18 and other phenyl chemistries.
• Limits ionization suppression and allows simple, MS-friendly mobile phases.
• Restek’s most popular LC stationary phase.

Stationary Phase Category: phenyl (L11)
Ligand Type: unique Biphenyl
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 15%
End-Cap: yes
Surface Area: 300 m²/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

Stationary Phase Category: fluorophenyl propyl (L43)
Ligand Type: pentafluorophenyl propyl
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 11%
End-Cap: yes
Surface Area: 300 m²/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

Particle: 5 µm, spherical
Pore Size: 60 Å
Carbon Load: n/a
End-cap: n/a
Surface Area: 450 m²/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

Highly retentive phase for normal phase separations. Very high surface area, Type B silica packing.

Stationary Phase Category: C8, octylsilane (L7)
Ligand Type: monomeric C8
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 12%
End-Cap: yes
Surface Area: 300 m²/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

Stationary Phase Category: polar-embedded alkyl (L68)
Ligand Type: proprietary polar functional embedded alkyl
Particle: 3 µm or 5 µm, spherical
Pore Size: 100 Å
Carbon Load: 12%
End-Cap: no
Surface Area: 300 m²/g
pH Range: 2.5 to 8
Maximum Temperature: 80 °C

• Proven performance for accurate, reliable ethyl glucuronide (EtG) and ethyl sulfate (EtS) analysis.
• Strong retention consistently resolves analytes from matrix interferences.
• Long column lifetime ensures consistent performance injection after injection.
• Fast, 4-minute, dilute-and-shoot LC-MS/MS analysis supports high sample throughput.